Comparison Chart: Heartworm Prevention Medicine For Dogs

Heartworm prevention is an essential part of protecting dogs from heartworm disease, a serious parasite transmitted through mosquito bites. Today's heartworm prevention products come in several forms, including monthly chewable tablets, topical treatments, and long-acting injections. Many of these medications contain active ingredients such as ivermectin, milbemycin oxime, moxidectin, or selamectin, which work by eliminating heartworm larvae before they can mature into adult worms. Because different products may also provide protection against other parasites like fleas, ticks, or intestinal worms, comparing options help pet owners choose the right solution for their dogs. This heartworm prevention product comparison chart provides a quick reference to help you review common heartworm preventives and understand the difference between available options.
| Dog Products / Compares to / Manufacturer / Administor |
Worms:Heart | Worms:Hook | Worms:Round | Worms:Whip | Worms:Tape | Fleas | Ticks | Mange | Earliest Age |
Active Ingredient |
|---|---|---|---|---|---|---|---|---|---|---|
| Dog Products:
Advantage Multi Compares to: . Manufacturer: Bayer Administor: Topical |
Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: YES | Tapeworm: - | Fleas: YES | Ticks: - | Mange: YES | Earliest: 7 weeks (and 3 lbs) |
Active Ingredient: Imidacloprid + Moxidectin |
| Dog Products:
Heartgard Plus
Compares to: . Manufacturer: Merial Administor: Chewable |
Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: - | Tapeworm: - | Fleas: - | Ticks: - | Mange: - | Earliest: 6 weeks | Active Ingredient: Ivermectin + Pyrantel |
| Dog Products: HeartShield Plus
Compares to: Iverhart Plus & Heartgard Plus Manufacturer: TruRx Administor: Chewable |
Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: - | Tapeworm: - | Fleas: - | Ticks: - | Mange: - | Earliest: 6 weeks | Active Ingredient: Ivermectin + Pyrantel |
| Dog Products:
Interceptor
Compares to: . Manufacturer: Elanco Administor: Flavor Tab |
Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: YES | Tapeworm: - | Fleas: - | Ticks: - | Mange: - | Earliest: 4 weeks (and 2 lbs) |
Active Ingredient: Milbemycin Oxime |
| Dog Products: Interceptor Plus Compares to: . Manufacturer: Elanco Administor: Chewable | Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: YES | Tapeworm: YES | Fleas: - | Ticks: - | Mange: - | Earliest: 6 weeks | Active Ingredient: Milbemycin Oxime + + Praziquantel |
| Dog Products: Iverhart Max
Compares to: . Manufacturer: Merck Administor: Chewable |
Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: - | Tapeworm: YES | Fleas: - | Ticks: - | Mange: - | Earliest: 8 weeks | Active Ingredient: Ivermectin + Pyrantel Pamoate + Praziquantel |
| Dog Products:
Iverhart Plus
Compares to: . Manufacturer: Merck Administor: Chewable |
Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: - | Tapeworm: - | Fleas: - | Ticks: - | Mange: - | Earliest: 6 weeks | Active Ingredient: Ivermectin + Pryrantel |
| Dog Products: PetTrust Plus
Compares to: Iverhart Plus & Heartgard Plus Manufacturer: FidoPharm Administor: Chewable |
Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: - | Tapeworm: - | Fleas: - | Ticks: - | Mange: - | Earliest: 6 weeks | Active Ingredient: Ivermectin + Pryrantel |
| Dog Products:
Sentinel Flavor Tabs
Compares to: . Manufacturer: Merck Administor: Flavor Tab |
Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: YES | Tapeworm: - | Fleas: YES | Ticks: - | Mange: - | Earliest: 4 weeks (and 2 lbs) |
Active Ingredient: Milbemycin Oxime + Lufenuron |
| Dog Products: Sentinel Spectrum Compares to: . Manufacturer: Merck Administor: Chewable | Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: YES | Tapeworm: YES | Fleas: YES | Ticks: - | Mange: - | Earliest: 6 weeks | Active Ingredient: Milbemycin Oxime + Lufenuron + Praziquantel |
| Dog Products:
Trifexis
Compares to: . Manufacturer: Elanco Administor: Chewable |
Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: YES | Tapeworm: - | Fleas: YES | Ticks: - | Mange: - | Earliest: 8 weeks (and 5 lbs) |
Active Ingredient: Spinosad + Milbemycin Oxime |
| Dog Products:
Tri-Heart Plus
Compares to: Iverhart Plus & Heartgard Plus Manufacturer: Merck Administor: Chewable |
Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: - | Tapeworm: - | Fleas: - | Ticks: - | Mange: - | Earliest: 6 weeks | Active Ingredient: Ivermectin & Pyrantel |
| Dog Products: Worm Shield
Compares to: Iverhart Plus & Heartgard Plus Manufacturer: Schuyler Administor: Chewable |
Heartworm: YES | Hookworm: YES | Roundworm: YES | Whipworm: - | Tapeworm: - | Fleas: - | Ticks: - | Mange: | Earliest: 6 weeks | Active Ingredient: Ivermectin + Pyrantel |

