(Zoetis Animal Health) FluSure XP/Respisure-ONE is for vaccination of healthy swine, including pregnant sows and gilts, 3 weeks of age or older as an aid in preventing respiratory disease caused by SIV subtypes H1N1, H1N2 and H3N2 and respiratory disease caused by M. hyopneumoniae for a period of 25 weeks. A duration of immunity of at least 10 weeks, as demonstrated by a significant reduction in lung lesions, has been established against SIV H3N2. Give 2 ml IM to healthy swine 3 weeks of age or older, followed by a single dose of FluSure XP approximately 3 weeks later. In young pigs, vaccinate after maternally derived antibodies to SIV have declined. Semiannual booster is recommended. FluSure XP/Respisure-ONE requires mixing.