(Immvac) Endovac-Beef with ImmunePlus is used in cattle for prevention of the effects of endotoxemia due to Escherichia coli, Salmonella typhimurium, Pasteurella multocida, and Mannheimia haemolytica. Endovac-Beef with ImmunePlus is derived mutagenically from Salmonella typhimurium bacterin Re-17. Inject 2 ml into the musculature of healthy cattle. Repeat in 2 or 3 weeks. Administer a 2 ml booster dose annually.