ZelNate DNA Immunostimulant for Cattle

ZelNate DNA Immunostimulant for Cattle aids in the treatment of bovine respiratory disease (BRD) due to Mannheimia haemolytica in cattle 4 months of age and older. ZelNate should be administered at the time of, or within 24 hours after, a perceived stressful event. ZelNate is a bacterial-produced plasmid DNA with a liposome carrier that stimulates the innate immune system in cattle. The innate immune system has been shown to provide a potent, rapid, nonspecific, protective response to infectious agents, such as those that can lead to Bovine Respiratory Disease (BRD). BRD is a serious condition that commonly causes lung lesions, reduced lung capacity, and mortality. As a stand-alone therapy, ZelNate has been shown to significantly reduce lung lesions associated with BRD when administered in the face of disease challenge, and to significantly reduce the risk of mortality when administered in the face of clinical BRD. ZelNate requires mixing. The freeze-dried product is packaged with two different sterile diluents. Mixing process must be completed in the proper order prior to use. Inject 2 ml IM at the time of, or within 24 hours after, a perceived stressful event (ie. weaning, shipping, commingling, or adverse environmental conditions). Do not administer within 21 days of slaughter.

While vaccines work with the adaptive immune response to target specific pathogens, sometimes requiring days or weeks to develop, immunostimulants trigger a rapid and broad response to infection via the innate immune system. The key difference between ZelNate and other immunostimulants lies in its revolutionary DNA-liposome complex. The ZelNate DNA has a unique code that mimics infection, causing the animal's immune system to recognize ZelNate as foreign. This jumpstarts the innate immune system in cattle.

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