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Comparison Chart: Heartworm Prevention Medicine For Dogs

Heartworm Prevention

Heartworm prevention is an essential part of protecting dogs from heartworm disease, a serious parasite transmitted through mosquito bites. Today's heartworm prevention products come in several forms, including monthly chewable tablets, topical treatments, and long-acting injections. Many of these medications contain active ingredients such as ivermectin, milbemycin oxime, moxidectin, or selamectin, which work by eliminating heartworm larvae before they can mature into adult worms. Because different products may also provide protection against other parasites like fleas, ticks, or intestinal worms, comparing options help pet owners choose the right solution for their dogs. This heartworm prevention product comparison chart provides a quick reference to help you review common heartworm preventives and understand the difference between available options.

Dog Products /
Compares to /
Manufacturer /
Administor
Worms:
Heart
Worms:
Hook
Worms:
Round
Worms:
Whip
Worms:
Tape
Fleas Ticks Mange Earliest
Age
Active
Ingredient
Dog Products: Advantage Multi
Compares to: .
Manufacturer: Bayer
Administor: Topical
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: YES Tapeworm: - Fleas: YES Ticks: - Mange: YES Earliest: 7 weeks
(and 3 lbs)
Active Ingredient: Imidacloprid +
Moxidectin
Dog Products: Heartgard Plus
Compares to: .
Manufacturer: Merial
Administor: Chewable
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: - Tapeworm: - Fleas: - Ticks: - Mange: - Earliest: 6 weeks Active Ingredient: Ivermectin +
Pyrantel
Dog Products: HeartShield Plus
Compares to: Iverhart Plus & Heartgard Plus
Manufacturer: TruRx
Administor: Chewable
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: - Tapeworm: - Fleas: - Ticks: - Mange: - Earliest: 6 weeks Active Ingredient: Ivermectin +
Pyrantel
Dog Products: Interceptor
Compares to: .
Manufacturer: Elanco
Administor: Flavor Tab
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: YES Tapeworm: - Fleas: - Ticks: - Mange: - Earliest: 4 weeks
(and 2 lbs)
Active Ingredient: Milbemycin
Oxime
Dog Products: Interceptor Plus
Compares to: .
Manufacturer: Elanco
Administor: Chewable
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: YES Tapeworm: YES Fleas: - Ticks: - Mange: - Earliest: 6 weeks Active Ingredient: Milbemycin
Oxime +
+ Praziquantel
Dog Products: Iverhart Max
Compares to: .
Manufacturer: Merck
Administor: Chewable
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: - Tapeworm: YES Fleas: - Ticks: - Mange: - Earliest: 8 weeks Active Ingredient: Ivermectin +
Pyrantel Pamoate +
Praziquantel
Dog Products: Iverhart Plus
Compares to: .
Manufacturer: Merck
Administor: Chewable
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: - Tapeworm: - Fleas: - Ticks: - Mange: - Earliest: 6 weeks Active Ingredient: Ivermectin +
Pryrantel
Dog Products: PetTrust Plus
Compares to: Iverhart Plus & Heartgard Plus
Manufacturer: FidoPharm
Administor: Chewable
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: - Tapeworm: - Fleas: - Ticks: - Mange: - Earliest: 6 weeks Active Ingredient: Ivermectin +
Pryrantel
Dog Products: Sentinel Flavor Tabs
Compares to: .
Manufacturer: Merck
Administor: Flavor Tab
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: YES Tapeworm: - Fleas: YES Ticks: - Mange: - Earliest: 4 weeks
(and 2 lbs)
Active Ingredient: Milbemycin Oxime +
Lufenuron
Dog Products: Sentinel Spectrum
Compares to: .
Manufacturer: Merck
Administor: Chewable
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: YES Tapeworm: YES Fleas: YES Ticks: - Mange: - Earliest: 6 weeks
Active Ingredient: Milbemycin Oxime +
Lufenuron +
Praziquantel
Dog Products: Trifexis
Compares to: .
Manufacturer: Elanco
Administor: Chewable
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: YES Tapeworm: - Fleas: YES Ticks: - Mange: - Earliest: 8 weeks
(and 5 lbs)
Active Ingredient: Spinosad +
Milbemycin Oxime
Dog Products: Tri-Heart Plus
Compares to: Iverhart Plus & Heartgard Plus
Manufacturer: Merck
Administor: Chewable
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: - Tapeworm: - Fleas: - Ticks: - Mange: - Earliest: 6 weeks Active Ingredient: Ivermectin &
Pyrantel
Dog Products: Worm Shield
Compares to: Iverhart Plus & Heartgard Plus
Manufacturer: Schuyler
Administor: Chewable
Heartworm: YES Hookworm: YES Roundworm: YES Whipworm: - Tapeworm: - Fleas: - Ticks: - Mange: Earliest: 6 weeks Active Ingredient: Ivermectin +
Pyrantel