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Respisure-ONE/ER Bac Plus is for vaccination of healthy swine 3 weeks of age or older, as an aid in preventing erysipelas caused by E. rhusiopathiae for a period of 20 weeks, and respiratory disease (pneumonia) caused by M. hyopneumoniae for a period of 23 weeks. For best results, vaccination of all swine in the herd is recommended. Primary vaccination: administer a single 2 ml IM dose to healthy swine 3 weeks of age or older. Follow with another dose of erysipelas protection approximately 3 weeks later. Semiannual revaccination with a single dose of Respisure-ONE/ER Bac Plus is recommended.