(Zoetis Animal Health) Vanguard Plus 5/CV is a 5-way + coronavirus Modified live plus killed coronavirus. For protection against canine distemper, adenovirus type 2 (and hepatitis), parainfluenza, parvovirus and coronavirus. Vanguard Plus 5/CV is for dogs 6 weeks of age or older. Give 1 ml IM or SQ. Give 3 doses, each 3 weeks apart. Annual revaccination with a single dose is recommended. Not for pregnant bitches. Requires mixing. Order syringes separately.